Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For

In this episode I explain how nicotine impacts the brain and body including its potent ability to enhance attention focus and alertness increase blood pressure and metabolism and reduce appetite. I discuss nicotine’s ability to increase the action of neurochemicals including dopamine norepinephrine and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods such as cigarettes vaping dip and snuff and how they each create their own unique experience and how they but not nicotine itself cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping including peer-reviewed clinical hypnosis tools antidepressants and alternative nicotine replacement (patches lozenges gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Maui Nui: https://mauinuivenison.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes visit hubermanlab.com Timestamps (00:00:00) Nicotine (00:02:47) Momentous Supplements (00:03:41) Tool: Brief Daily Meditation & Focus (00:05:59) The Arrow Model of Focus Alpha GPC & Garlic Supplements (00:10:43) Thesis InsideTracker ROKA (00:14:35) Nicotine Effects vs. Methods of Delivery Acetylcholine (00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors (00:25:12) Nicotine & Effects on the Brain: Appetite Dopamine & GABA (00:30:58) AG1 (Athletic Greens) (00:32:11) Nicotine Acetylcholine & Attentional “Spotlighting” (00:37:29) Nicotine Norepinephrine & Alertness/Energy (00:41:10) Nicotine & Effects on Appetite & Metabolism (00:46:47) Nicotine & Effects on Body: Sympathetic Tone (00:51:29) Nicotine & Cognitive Work vs. Physical Performance (00:55:08) Nicotine Delivery Methods & Side Effects Young People & Dependency (00:58:35) Smoking Vaping Dipping & Snuffing: Carcinogens & Endothelial Cells (01:02:34) Smoking Vaping Dipping & Snuffing: Negative Impacts on Lifespan & Health (01:09:23) How to Quit Smoking Nicotine Cravings & Withdrawal (01:13:56) Vaping & Nicotine Rates of Effect Onset Dopamine Addiction & Depression (01:25:06) Tool: Quitting Smoking & Clinical Hypnosis Reveri (01:30:16) Bupropion (Wellbutrin) & Quitting Smoking (01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking Nicotine Patch/Gum (01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal The “First Week” Strategy (01:51:39) Zero-Cost Support YouTube Feedback Spotify & Apple Reviews Sponsors Momentous Supplements Neural Network Newsletter Instagram Twitter Facebook Title Card Photo Credit: Mike Blabac Disclaimer

Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping | Episode 90

Huberman Lab